The combined action of vanadium citrate and chromium decreased the content of TBA-active products and increased the activity of antioxidant enzymes in intact animals. ![]() We determined the content of lipid peroxidation products: lipid hydroperoxides and TBA-active products and the activity of antioxidant enzymes: superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and the content of reduced glutathione. Materials for the research were homogenates of pancreas tissues of rats. In the animals from groups III and IV, diabetes mellitus was induced by intraperitoneal injection of 5% solution of alloxan monohydrate in the amounts of 150 mg/kg of body weight. Rats from groups І (control) and ІІІ were given pure water without any additives groups ІІ and ІV were given water with the solution of vanadium citrates, in the amounts of 0.5 μg V/ml of water, and chromium citrates – 0.1 μg Cr/ml of water. The animals were divided into four groups. The research was conducted on 32 laboratory rats of the Wistar line. Vanadium and Chromium compounds are antioxidants, so they can be considered as a prophylactic agent to slow the progression of diabetes and the risk of complications. ![]() ![]() The aim of the study of the work is to investigate the influence of vanadium and chromium citrate on the antioxidant activity in the tissues of rats with alloxan diabetes mellitus. Diabetes increases oxidative stress, which causes exhaustion of the antioxidant system. KRYPYNSKYI LVIV MEDICAL ACADEMYĭiabetes mellitus, vanadium citrate, chromium citrate, antioxidant system, rats Abstract INSTITUTE OF ANIMAL BIOLOGY NAAS, LVIV A.
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